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Abortion, Civil Rights, Healthcare and other Social Issues Abortion, Civil Rights, Homosexuality, Education, Healthcare and other such issues

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Old 09-04-2007
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Should Human's strive for DNA perfection ?

Mapping own DNA changes scientist's life

Quote:
Venter says it's just the beginning of a new era of personal genomics. "For the first time, we can answer almost any question of what's genetic, what's the environment. Our genes can tell us probabilities of what might happen and give us a chance to do something about it."

Today, Venter probably knows more about his own biology than any other human being. But as it stands now, the little that is understood about DNA is related to disease. For now, much of his insight is bad news.
~@~

While reading the above article, it struck me that one day some scientist or group of scientists will be able to dissect, manipulate, splice a DNA sequence altering it's natural makeup and eliminating the inherent flaws.

Would this be a wise course of action in furthering the evolution of Mankind?

Imagine if actual human-beings were produced that had perfect genetics free of flaws which cause disease and the limitations of longevity.
Now overpopulation would be a concern if humans were to live healthy productive lives without genetically inheritable diseases. Perhaps the only avenue for humanity persuing this quest would be in space exploration?
Then again, would these people be a true representation of Man to whomever they may encounter ?

Quote:
Venter says it gives him more motivation than just a simple family history. "In my case it gives me a little bit more motivation to try and persistently stick with healthy habits because you don't have the excuse of saying ... you know, I don't really have those traits. ... I know what is in my genetic code," he says.

He's also identified a gene linked to Alzheimer's disease. It was a surprise to him, given that he had absolutely no family history of the illness. Now, he takes statins, or drugs that lower the cholesterol in the blood, because of their proven beneficial heart effects and possible memory protection.

Venter says he takes all the new discoveries in stride. "I'll be watching it obviously and looking for preventative ideas or hints of it. I'm not afraid of it in the sense that I feel it's a sentence, because I know that it is a statistical probability."

So far, he's found genetic proof of links to blindness, alcoholism, lactose intolerance, substance abuse, hypertension, obesity, even the type of earwax he has.

But the genome is far from perfect. He doesn't see it as an absolute, but rather as a clue. It's an indicator of risk, but not a certainty. For example, Venter has a normal risk for skin cancer, but still he recently battled melanoma.

The road to personal discovery has been long and contentious for Venter. In 2000, Venter led a private team that raced the publicly funded Human Genome Project to complete the first working drafts of the human genome, creating a blueprint for the DNA of all humanity. The public project eventually took 13 years and $3 billion to complete. It was a composite of 269 people's DNA.

As then-president of the private company Celera Genomics, Venter matched the public effort at a fraction of the cost and the time. Celera's genome was a composite of five people's DNA. Years later, it was revealed that much of the genome was, in fact, his own.

Then-President Bill Clinton declared the race a tie, pronouncing the result "the most important, most wondrous map ever produced by humankind."

Since then, Venter has left Celera and has started the J. Craig Venter Institute, which is looking for a faster way to crack the DNA code. Over the years, he has used the Celera work and $10 million to analyze DNA, including his own.

Given his past, Venter says he has carved out an unlikely place in history for himself. He says he almost flunked out of high school and spent most of youth surfing in California. He would later serve as a medic in Vietnam and eventually choose to become a scientist.

~snip~
Consider the above question: Should Man persue this course if proven achievable?

The way mankind has been taught to view life and death are quite possibly about to be rewritten.

Quote:
The Enchiridion
By Epictetus
Written 135 A.C.E.
Quote:
1. Some things are in our control and others not.
Things in our control are opinion, pursuit, desire, aversion, and, in a word, whatever are our own actions.

Things not in our control are body, property, reputation, command, and, in one word, whatever are not our own actions.

The things in our control are by nature free, unrestrained, unhindered; but those not in our control are weak, slavish, restrained, belonging to others. Remember, then, that if you suppose that things which are slavish by nature are also free, and that what belongs to others is your own, then you will be hindered. You will lament, you will be disturbed, and you will find fault both with gods and men. But if you suppose that only to be your own which is your own, and what belongs to others such as it really is, then no one will ever compel you or restrain you. Further, you will find fault with no one or accuse no one. You will do nothing against your will. No one will hurt you, you will have no enemies, and you not be harmed.

Aiming therefore at such great things, remember that you must not allow yourself to be carried, even with a slight tendency, towards the attainment of lesser things. Instead, you must entirely quit some things and for the present postpone the rest. But if you would both have these great things, along with power and riches, then you will not gain even the latter, because you aim at the former too: but you will absolutely fail of the former, by which alone happiness and freedom are achieved.

Work, therefore to be able to say to every harsh appearance, "You are but an appearance, and not absolutely the thing you appear to be." And then examine it by those rules which you have, and first, and chiefly, by this: whether it concerns the things which are in our own control, or those which are not; and, if it concerns anything not in our control, be prepared to say that it is nothing to you.
There is one more ethical~moral question Man should ponder before going off on this path.

Religion
Quote:
People are basically the same world-wide.
They commit the same sins, experience the same needs, and sense the same guilt. They suffer the same diseases, and instinctively search for the same peace, regardless of race, colour, sex or religious background. When anyone is really Born Again, they react with the same overwhelming satisfaction.
If the first generations of a new genetically altered human beings have an advantage over natural human-beings, history would enivitably be written in these generations favor.
Would one Religious belief eventually dominate the planet?
Which one should they emulate ?

Would a genetically superior human race retain the diversity that we share today ?

Lists of Famous Adherents of Various Religious Groups
lists of prominent people (actors, politicians, authors, U.S. presidents, artists, musicians, Supreme Court justices, film directors, etc.) classified by religious affiliation.
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Last edited by Owl Mirror; 09-04-2007 at 06:14 PM.
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

Knowing one's DNA sequence hardly gives knowledge of all of one's predispositions. We just don't know what all of that sequence *does*. For example, Ventr says he has no family history of Alzheimers, but found on gene taht is linked to it...and now he's taking an experimental treatment for a disease he might be suceptable to? This sounds a bit crazy to me. He ought to know that most traits are the result of multiple gene interactions, and these are far from worked out. Maybe he has other genes that are protective, and this is why there is no family history; only now he may screw up his liver with the statins.
At any rate, these discoveries will be used for somatic genetic therapy to treat genetic diseases, but germ line alteration is forbidden, and with good reason I think. If you want to know how we do when we have leave to alter a species even just using selective breeding look at dogs; what a mess! We've got psychotic breeds, breeds that can't give birth without a c-section, breeds that can barely breathe...no, we've got no buisness fooling with human inheritance.
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Otter View Post
Knowing one's DNA sequence hardly gives knowledge of all of one's predispositions. We just don't know what all of that sequence *does*. For example, Ventr says he has no family history of Alzheimers, but found on gene taht is linked to it...and now he's taking an experimental treatment for a disease he might be suceptable to? This sounds a bit crazy to me. He ought to know that most traits are the result of multiple gene interactions, and these are far from worked out. Maybe he has other genes that are protective, and this is why there is no family history; only now he may screw up his liver with the statins.
At any rate, these discoveries will be used for somatic genetic therapy to treat genetic diseases, but germ line alteration is forbidden, and with good reason I think. If you want to know how we do when we have leave to alter a species even just using selective breeding look at dogs; what a mess! We've got psychotic breeds, breeds that can't give birth without a c-section, breeds that can barely breathe...no, we've got no buisness fooling with human inheritance.

Quote:
but germ line alteration is forbidden
Many things are forbidden, such as a poppy

UNODC - Afghanistan ends opium poppy cultivation - Update June 2
Afghanistan: Poppy, Heroin Trade Flourishing As Government Fails To Provide Alternatives
Afghanistan: Poppy Eradication Failing And Taliban Benefitting - RADIO FREE EUROPE / RADIO LIBERTY

Why do you believe "germ line alteration is forbidden" and something that will remain forbidden AND
100% adhered to by everyone, for all time ?
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

"DNA perfection"?

No, I don't think so, because I don't think we can really know what it means...
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Steve View Post
"DNA perfection"?

No, I don't think so, because I don't think we can really know what it means, so how would we know when it's "perfect"?
In past history, we didn't "really know" flight was possible.
And although it has not yet been perfected, it has changed Mankinds existance on this tiny globe forever.

Same could be said of the first discovery of flint and the accompaning discovery of Gunpowder.

Knowledge and Discovery can never be put back in the bottle once it exists.
Although perhaps dangerous, the knowledge of manipulating the human genome exists.
Someone is bound to try, even though they may never "know when it's "perfect".
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Owl Mirror View Post
....
Why do you believe "germ line alteration is forbidden" and something that will remain forbidden AND
100% adhered to by everyone, for all time ?
For now, it is forbidden. You are correct that people do break laws and do things that are forbidden. If a scientist starts research in germ line alteration, then their funding will be cut immediately. As scientific research is costly, s/he'll need good luck continuing in her/his basement or garage.
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

If you could guarantee that your children and grand children would not get cancer, heart disease or diabetes, would you?
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Old 09-09-2007
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Re: Should Human's strive for DNA perfection ?

The idea of DNA perfection is an interesting one, but I am more interested in asking who decides what constitutes perfection? Where is the line drawn? If we eliminate the gene the causes alcoholism? What about red hair? The gay gene? How similar is what you're proposing in the OP to the Aryan notion that Hitler tried to genetically develop in the 40s?
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Old 09-10-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Owl Mirror View Post
Someone is bound to try, even though they may never "know when it's "perfect".
Which is reason enough to not pursue it...
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Old 09-10-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Steve View Post
Which is reason enough to not pursue it...

Steve, please take this comparison in consideration. {not intended to go Off-topic}

Ex. : The U.S. experiment promoting democracy, mainly in the Middle East. ...
Quote:
The spread of democracy has become the central tenet in the Bush administration's foreign policy.
But what exactly makes a country democratic?
Quote:
Originally Posted by Steve View Post
Which is reason enough to not pursue it...
Hmm, "know when it's "perfect" ?
With your rationale, Spreading Democracy should never be attempted since we shall never "know when it's "perfect" .

Human-beings are capable of creative as well as destructive achievements.

Good intentions can often lead to disastrous results,
like the U.S. experiment promoting democracy solely in terms of free elections.

" Which is reason enough to not pursue it. ... "

~@~

On Topic again, the simple fact that this knowledge exists leads to the advent of an attempt being made to improve
the genetic makeup of our species. I'm not saying that Dr Frankenstien has reared his ugly head.
The most noble of intentions may be put forth as their intended goal.
As for financing this type of endeavor, It's been said that he who has all the toys, WINS

And that is where we must watch the closest because the investors will have control of issues such as
the make-up of the racial strain being produced, the eventual educational interests of the offspring, including religious instructions.

The famous line from the story DUNE rings true in most every aspect of Man's society.
"He who controls the spice, controls the universe"

It is therefore not a question of is this possible or probable but, who and how shall it be controlled ?
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Old 09-10-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Owl Mirror View Post
Should Human's strive for DNA perfection ?
Perfection should be defined.

Quote:
Originally Posted by Owl Mirror View Post
....Should Human's strive for DNA perfection ?
What is perfection?
Quote:
Originally Posted by Owl Mirror View Post
.... Would this be a wise course of action in furthering the evolution of Mankind?...
Here is one reason why not:
Quote:
Originally Posted by Otter View Post
Knowing one's DNA sequence hardly gives knowledge of all of one's predispositions….
Maybe he has other genes that are protective, and this is why there is no family history; only now he may screw up his liver with the statins….
Here is another reason why not:
Quote:
Originally Posted by Otter View Post
…. If you want to know how we do when we have leave to alter a species even just using selective breeding look at dogs; what a mess! We've got psychotic breeds, breeds that can't give birth without a c-section, breeds that can barely breathe...no, we've got no buisness [sic] fooling with human inheritance.
Quote:
Originally Posted by Owl Mirror View Post
....Now overpopulation would be a concern if humans were to live healthy productive lives without genetically inheritable diseases. Perhaps the only avenue for humanity persuing [sic] this quest would be in space exploration?…
If this “perfection” is pursued to achieve the elimination of genetic diseases, the assumption of a resulting over-population is not a necessary result. The effects of disease via mutation and gene interactions are not considered and would have effects on creating disease and on the proposed over-population.
Quote:
Originally Posted by Owl Mirror View Post
....Then again, would these people be a true representation of Man to whomever they may encounter ?
Not many would know; there are too many variables to consider.

Quote:
Originally Posted by Owl Mirror View Post
....Consider the above question: Should Man persue [sic] this course if proven achievable?…
Here is one reason why not:
Quote:
Originally Posted by Otter View Post
Knowing one's DNA sequence hardly gives knowledge of all of one's predispositions….
Maybe he has other genes that are protective, and this is why there is no family history; only now he may screw up his liver with the statins….
Here is another reason why not:
Quote:
Originally Posted by Otter View Post
…. If you want to know how we do when we have leave to alter a species even just using selective breeding look at dogs; what a mess! We've got psychotic breeds, breeds that can't give birth without a c-section, breeds that can barely breathe...no, we've got no buisness [sic] fooling with human inheritance.

Quote:
Originally Posted by Owl Mirror View Post
....Would one Religious belief eventually dominate the planet?
Which one should they emulate ?…
If the Constitution is still in place in your future, the questions are moot.

Quote:
Originally Posted by Owl Mirror View Post
....Would a genetically superior human race retain the diversity that we share today ?…
There would continue to be diversity due to mutations and unpredictable gene interactions, still.

Quote:
Originally Posted by Owl Mirror View Post
....On Topic again, the simple fact that this knowledge exists leads to the advent of an attempt being made to improve
the genetic makeup of our species….
…through somatic genetic therapy and preventive measures for identified disease, assuming all gene interactions can be identified, especially positive or canceling gene interactions. This is very different from germ line alterations.
Quote:
Originally Posted by Owl Mirror View Post
....
As for financing this type of endeavor, It's been said that he who has all the toys, WINS….
Vide infra with respect to ethics and reasonable research in the scientific community.

Quote:
Originally Posted by Owl Mirror View Post
....And that is where we must watch the closest because the investors will have control of issues such as
the make-up of the racial strain being produced, the eventual educational interests of the offspring, including religious instructions.

The famous line from the story DUNE rings true in most every aspect of Man's society.
"He who controls the spice, controls the universe"

It is therefore not a question of is this possible or probable but, who and how shall it be controlled ?
You’ve answered your own questions, but we can still try:

Altering germ lines is unethical. Funding, the majority of which is controlled by the public, would be immediately halted if research in altering germ lines is pursed with the goal of creating a “master race” rather than a goal of somatic therapy. Scientific research is expensive. With no funding, it would not continue.

Altering germ lines is impractical. The fact that there will always be mutations is one reason. Another reason is the effective control of unpredictable gene interactions.

Any single scientist who would propose this as a viable area of research would be foolish and lose their credibility in the scientific community and end up working alone. Granted, the cited scientist did find his genome but he admits that his genome made up the majority of that studied under Celera’s Humane Genome Project. The genes responsible for many genetic diseases have yet to be defined. The interactions of combination of genes have yet to be defined. Mutations are not only possible, but also probable, and cannot be predicted as of yet.



It my hope and the hope of many other scientists that fear-mongering with respect to science can be curtailed with the spread of knowledge in the area.
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Old 09-10-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Owl Mirror View Post
Steve, please take this comparison in consideration. {not intended to go Off-topic}
And, yet, you so willingly do...

Quote:
Hmm, "know when it's "perfect" ?
With your rationale, Spreading Democracy should never be attempted since we shall never "know when it's "perfect" .
We already know Democracy isn't "perfect"? Should we just shit-can it?

Quote:
And that is where we must watch the closest because the investors will have control of issues such as the make-up of the racial strain being produced, the eventual educational interests of the offspring, including religious instructions.
That certainly sounds like an argument against it than in favor of it...

Quote:
It is therefore not a question of is this possible or probable but, who and how shall it be controlled ?
It is, which also sounds like an argument against it.

I'm not devating the possibility or probabilty, but just whether or not it should be done.

Can you define what DNA 'perfection" is?
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Old 09-10-2007
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Re: Should Human's strive for DNA perfection ?

Quote:
Originally Posted by Si modo View Post
~snip~
It my hope and the hope of many other scientists that fear-mongering with respect to science can be curtailed with the spread of knowledge in the area.
At first I was impressed at the answers coming from a boilermaker, then in the end you claim "many other scientists ".
So which is it or are you a scientist who moonlights as a boilermaker ?
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